Hmmm... Strange. I don't know why mine won't let me apply the settings.Nope.
In fact, I did a new build 2 weeks ago (skylake-based PC, fresh install of Win 10 build 1511) and the T300 driver from http://ts.thrustmaster.com/eng/index.php?pg=view_files&gid=1&fid=2&pid=374&cid=15 worked fine. I can apply degrees of rotation and it sticks without issue.
Nope